Molecular Formula | C15H33NO7 |
Molar Mass | 339.42 |
Density | 1.046 |
Boling Point | 409.5±40.0 °C(Predicted) |
pKa | 8.74±0.10(Predicted) |
Storage Condition | -20°C |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
biological activity | m-PEG7-Amine is a PROTAC connection bridge and belongs to PEG class. m-PEG7-Amine can be used to synthesize a series of PROTAC molecules. m-PEG7-Amine is a degradable (cleavable) ADC connection bridge for the synthesis of antibody drug conjugates (ADCs). |
target | Cleavable PEGs |
in vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |